The utility of MDR-100 and -200 with TNT has been demonstrated by rescuing necrotizing tissues and whole limbs using murine and porcine models of injury-induced ischemia. In rodent studies, skin cells were reprogrammed to endothelial cells in injured legs which devoid of blood flow. Within one-week, blood vessels started to appear in the injured leg, and by the second week, the leg was successfully rescued.
The utility of MDR-300 with TNT for insulinogenic skin reprogramming has been demonstrated by lowering the level of blood glucose in Streptozotocin (STZ)-induced diabetic animal models after treatment on the skin. Further confirmation is being pursed with various diabetes models.
The utility of MDR-400 with TNT for neurogenic skin reprogramming has been demonstrated by inducing neuronal cells in the skin of live animals. Induced neuron displayed a similar gene expression profile of developing brain with electrophysiological activity. Induced neurons also became highly neurotrophic, overexpressing nerve growth factor and other related proteins essential for the development and maintenance of peripheral nerves.